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You searched IISERK - Author: Weiss, Martin.
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Call Number
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616/.042
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Title
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Adenoviral vectors for gene therapy [electronic resource] / edited by David T. Curiel, Joanne T. Douglas.
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Publication
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Amsterdam ; Boston : Academic Press, c2002.
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Material Info.
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xxviii, 677 p. : ill. ; 24 cm.
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Summary Note
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Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials.
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Notes
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Includes bibliographical references.
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Notes
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Adenovirus Structure -- Biology of Adenovirus Cell Entry -- Adenovirus Replication -- Adenoviral Vector Construction I: Mammalian Systems -- Adenoviral Vector Construction II: Bacterial Systems -- Propagation of Adenoviral Vectors: Use of PER.C6 Cells -- Purification of Adenovirus -- Targeted Adenoviral Vectors I: Transductional Targeting -- Targeted Adenoviral Vectors II: Transcriptional Targeting -- Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer -- Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer -- Innate Immune Responses to in Vivo Adenovirus Infection -- Humoral Immune Response -- Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy -- High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications -- Xenogenic Adenoviral Vectors -- Hybrid Adenoviral Vectors -- Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer -- Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease -- Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases -- Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations -- Imaging Adenovirus-Medicated Gene Transfer.
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Notes
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Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2007.
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ISBN
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9780121995041
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ISBN
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0121995046
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Subject
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Gene Therapy.
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Subject
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Adenoviruses.
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Subject
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Gene Therapy methods.
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Subject
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Adenoviridae.
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Subject
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Genetic Vectors therapeutic use.
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Subject
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Thérapie génique.
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Subject
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Adénovirus.
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Subject
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Adenovírus.
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Subject
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Genes virais.
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Subject
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Vírus de dna.
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Subject
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Electronic books.
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Added Entry
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Curiel, David.
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Added Entry
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Douglas, Joanne T.
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Added Entry
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ScienceDirect (Online service)
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Date
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Year, Month, Day:01405141
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Link
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An electronic book accessible through the World Wide Web; click for information ScienceDirect
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Link
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Publisher description
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Link
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Table of contents
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